DR. VIBIN RAMAKRISHNAN
Research Interests
Protein
Folding and design: Research on protein folding and
design are mutually complementary. A design attempt, even an
unsuccessful one will contribute to the understanding of the folding
phenomena. On the other hand a successful design requires knowledge of
the process by which the protein folds. Investigation of folding
pathways, possible transition states and kinetics can increase the
success rate in designing new protein molecules with tailor made
functions. It can also illumine research efforts on protein
mis-folding/aggregation and possible therapeutic intervention at a
later stage.
Biomarkers/Biosensors:
Proposed project envisages design of artificial hetero-tactic protein
constructs pregnant with a functional moiety. This functional molecule
can act as a transducer. The protein scaffold and the transducer
molecule together can be programmed for specific targets.
PUBLICATIONS
- Vibin Ramakrishnan;
Ranjit Ranbhor and Susheel Durani. Existence of Specific
"Folds" in Polyproline-II Ensembles of an Unfolded Alanine Peptide
Detected by Molecular Dynamics. Journal of American
Chemical Society (2004) 126, 16332- 16333.
- Vibin Ramakrishnan;
Ranjit Ranbhor and Susheel Durani. Probing Main Chain Roles
in Protein Structure and Folding Stereochemically. A Simulated
Annealing Folding Study of Isotactic, Syndiotactic and Heterotactic
Polypeptides. Biopolymers (2005) 78, 96-105.
- Vibin Ramakrishnan;
Ranjit Ranbhor; Anil Kumar and Susheel Durani. The link between
Sequence and Conformation in Protein Structures appears to be
Stereochemically Established. Journal of
Physical Chemistry B (2006) 110, 9314-9323.
- Ranjit Ranbhor; Vibin
Ramakrishnan; Anil Kumar and Susheel Durani. The
Interplay of Sequence and Stereochemistry in defining Conformation in
Proteins and Polypeptides. Biopolymers (2006)
83, 537-545
