Dr. Urvashi Sharma
DBT-Ramalingaswami Fellow, Structural biology of therapeutic targets
Dr. Urvashi Sharma graduated with a master’s degree in Biochemistry from Devi Ahilya Viswavidyalaya (DAVV), Indore. She persuaded her PhD in structural biology and biochemistry from CSIR-National Chemical Laboratory (NCL), PUNE under supervision of Prof. Dr. C. G. Suresh, where she deciphered the crystal structures of plant lectins recognizing complex sugars using X-ray crystallography. Later she secured postdoctoral position in collaborative team of Drs Nushin Aghajari and David JS Hulmes, at CNRS-Institute of biology and chemistry of proteins (IBCP) Lyon, France. Along with colleagues at IBCP, she investigated into the structural mechanisms of procollagen chain trimerization and regulation of procollagen processing. She moved to Vlaams Instituut voor Biotechnologie (VIB)/UGhent, Belgium in the Advance live cell imaging group of Prof. Daniel VanDamme to contribute into structural characterization of novel hetero-hexameric Tplate complex of plants (850 kDa) playing key role in Clathrin mediated endocytosis by using a combination of Cryo-EM/X-ray crystallography methods.
Dr Sharma’s latest postdoctoral work into Prof Ravi Acharya’s group at University of BATH, UK included Neprilysin-inhibitor binding studies in order to design safer drugs to treat hypertension/Cardiovascular diseases (CVDs).
“Dr. Sharma has joined IBAB in July 2020 as a DBT-Ramalingaswami fellow to initiate target validation of some of the novel Glycosyl transferases (GTs) of Mycobacterium tuberculosis.
Further details are to be found at https://www.ibab.ac.in/urvashi-sharma/