Gayatri Saberwal

Gayatri Saberwal

Faculty Scientist and Dean (Academic Affairs)

Research Focus Key Words

policy research, clinical trial databases, entrepreneurship, patents

Background

I obtained my MSc at the Jawaharlal Nehru University, New Delhi, and my PhD in the life sciences at the Centre for Cellular and Molecular Biology, Hyderabad. I then did post-doctoral work at the Weill Medical College of Cornell University, New York. I have been at IBAB since it was established in 2001. At IBAB I switched from being a biologist to being a policy researcher.

Education

  1. Msc: Jawaharlal Nehru University, Delhi
  2. PhD: Centre for Cellular and Molecular Biology, Hyderabad.
  3. Post-doctoral work: Weill Medical College of Cornell University, New York

Professional experience

Primarily at IBAB.

Research Interest Profile

We study the health-related industries and issues around them. We also write general articles and editorials about these issues.

Group Members:

  1. Dr. Mohua C Choudhury
  2. Dr. Sangeeta Kumari
  3. Dr. Nisha Venugopal
  4. Indraneel Chakraborty

Collaborators:

  1. Dr. K. Srinivasan, St John’s Research Institute
  2. Dr. Savitha D, St. John’s Medical College
  3. Dr. H. S. Subramanya, IBAB
  4. Dr. S. Thiyagarajan, IBAB

Funders:

Our work has been supported by

1. The Wadhwani Foundation
2. Institut Merieux
3. Internal funds from IBAB

Publications and Patents:
Research Publications

  1. Kumari, S. Mohan, A. and Saberwal, G
    Hidden duplicates: 10s or 100s of Indian trials, registered with ClinicalTrials.gov, have not been registered in India, as required by law.
    PLoS One 15(6): e0234925 (2020).
  2. Pillamarapu M, Mohan A and  Saberwal G
    Response to the Letter on: “An analysis of deficiencies in the data of interventional drug trials registered with Clinical Trials Registry – India”.
    Trials 21: 39 (2020).
  3. Pillamarapu, M., Mohan, A. and Saberwal, G.
    An analysis of deficiencies in the data of interventional drug trials registered with Clinical Trials Registry – India.
    Trials 20: 535 (2019).
  4. Choudhury M. C. and Saberwal, G.
    The origins, achievements, and challenges of orphan medicinal product organizations in India: An interview-based study.
    Orphanet J Rare Dis. 14, 241 (2019).
  5. Choudhury M. C. and Saberwal, G.
    The role of patient organizations in the rare disease ecosystem in India: An interview-based study.
    Orphanet J Rare Dis. 14:117 (2019)
  6. Chaturvedi, N, Mehrotra, B, Kumari, S, Gupta, S, Subramanya, H S and Saberwal, G.
    Some data quality issues at ClinicalTrials.gov.
    Trials 20:378 (2019)
  7. Dash, S. P. and Saberwal, G.
    The bio-­incubation boom in India.
    Current Science 115, 228–233 (2018)
  8. Mehrotra, B. and Saberwal, G.
    Patents protecting biologics or small molecule drugs are litigated, not others awarded to drug discovery companies.
    Journal of IP Rights, 21, 149-156 (2016).
  9. Keezhupalat, S.M., Naik, A., Gupta, S., Raghunathan, S. and Saberwal,G.
    An analysis of sponsors/collaborators of 69,160 drug trials registered with ClinicalTrials.gov
    PLOS ONE 11(2): e0149416. doi:10.1371/journal.pone.0149416 (2016)
  10. Saberwal, G.
    India’s intellectual property-based biomedical start-ups.
    Current Science, 110, 167-171 (2016)
  11. Jaroslawski, S. and Saberwal, G.
    In eHealth in India today, the nature of work, the challenges and the finances: an interview based study.BMC Medical Informatics and Decision Making, 14, 1-12 (2014) 
  12. Kumari, S. and Saberwal, G.
    Patent maintenance by Indian pharma and bio-pharma companies.
    Asian Biotechnology Development Review, 15, 69-77 (2013)
  13. Jaroslawski, S. and Saberwal, G.
    Case studies of innovative medical device companies from India: Barriers and enablers to development.BMC Health Services Research, 13, 199-207 (2013)  
  14. Saberwal, G. Giving voice to India’s entrepreneurs.
    Nature Biotechnology 31, 104-107 (2013)
  15. Marimuthu, G., Kumari, S., Kandasamy, M., Raghunathan, S. and Saberwal, G.
    Patents protecting biologics or small molecule drugs are usually maintained.
    Nature Biotechnology, 30, 50-53 (2012)
  16. Soby, S, Sebastian, T.E. and Saberwal, G.
    US patent holdings of Indian non-corporate entities.
    Asian Biotechnology Development Review, 14, 21-33 (2012)
  17. Soby, S., Kandasamy, M. and Saberwal, G
    Work outsourced to Indian biotech and pharma companies is not yet significantly innovative.
    Current Science, 102, 401-404 (2012)
  18. Sebastian, T.E., Pattnayak, J.P., Soby, S and Saberwal, G.
    Patent holdings of Indian pharmaceutical and biotechnology companies in international markets of different sizes.
    Asian Biotechnology Development Review, 13, 17-37 (2011)
  19. Saberwal, G.
    Seeding a skilled workforce.
    Nature Biotechnology, 27, 773-775 (2009)
  20. Sebastian, T.E., Chandra Bindu, Y. and Saberwal, G.
    Patent holdings of US biotherapeutic companies in major markets.
    Drug Discovery Today, 14, 442-445 (2009)
  21. Sundaramoorthy, S., Chandra Bindu, Y. , Mehdiratta, R. and Saberwal, G.
    The US patent holdings of homegrown Indian biotech and pharma companies.Current Science, 96, 252-259 (2009)
  22. Parida, D.K, Mehdiratta, R. and Saberwal, G.
    How many patents does a bio-therapeutics company need?
    Nature Biotechnology, 26, 763-766 (2008)
  23. Saberwal, G
    New pharma-biotech company formation in India
    Nature  Biotechnology, 24, 499-501 (2006)
  24. Andersen, O.S., Saberwal, G., Greathouse, D.V. and Koeppe, R.E., II.
    Gramicidin channels – a solvable membrane “protein” folding problem. Indian Journal of Biochemistry and Biophysics 33, 331–342 (1996)
  25. Saberwal, G., Thennarasu, S., Dhople, V.M., Jagannadham, M.V. and Nagaraj, R.
    Studies on the synthesis of the toxins pardaxin, δ-toxin and their analogues by solid-phase synthesis.Proceedings of the Indian Academy of Sciences (Chemical Sciences) 106, 1109–1121 (1994)
  26. Koeppe, R.E., II, Greathouse, D.V., Jude, A., Saberwal, G.,Providence, L.L. and Andersen, O.S. Helix
    sense of gramicidin channels as a “nonlocal” function of the primary sequence. The Journal of Biological Chemistry 269, 12567–12576 (1994)
  27. Saberwal, G. and Nagaraj. R.
    Cell-lytic and antibacterial peptides that act by perturbing the barrier function of membranes: facets of their conformational features, structure-function correlations and membrane-perturbing abilities.
    Biochimica et Biophysica Acta 1197, 109–131 (1994)
  28. Saberwal, G. and Nagaraj, R.
    Conformations of peptide fragments comprising the amino-terminal, central, and carboxyl-terminal regions of a membrane-active polypeptide. Build up of secondry structure in Pardaxin.
    The Journal of Biological Chemistry 268, 14081–14089 (1993)
  29. Saberwal, G. and Nagaraj, R.
    Interaction of hydrophobic peptides with model membranes: slow binding to membranes and not subtle variations in pore structure is responsible for the gradual release of entrapped solutes.
    Biochimica et Biophysica Acta 1151, 43–50, (1993)
  30. Vairamani, M., Srinivas, R., Viswanadha Rao, G.K., Nagaraj, R., Laxma Reddy, G. and Saberwal, G.
    Mass spectra of t-butlyoxycarbonyl (BOC)-protected peptides.
    Organic Mass Spectrometry 25, 97–100 (1990)
  31. Saberwal, G. and Nagaraj, R.
    A synthetic peptide corresponding to the hydrophobic amino terminal region of pardaxin can perturb model membranes of phosphatidyl choline and serine.
    Biochimica et Biophysica Acta 984, 360–364 (1989)

Series Of Blog Posts At Nature Biotechnology

  1. Reviewing a mythbreaker
  2. Clinical trials and beyond
  3. Australia’s government and biotech
  4. Building biotech in Australia
  5. Fueling Australian biotechs

Series Of Articles In Current Science

  1. Saberwal, G.
    Breaking all the rules, at lightning speed (Editorial)
    Curr. Sci. 119, 7- 8 (2020)
  2. Saberwal, G.
    India to power the more widespread use of biosimilars? (Guest Editorial)
    Curr. Sci. 116, 1451–1453 (2019)
  3. Subramanya, H. S. and Saberwal, G.
    India needs more policy research. (Guest Editorial)
    Curr. Sci. 116, 1279–1280 (2019)
  4. Choudhuri, M. C., and Saberwal, G.
    Patient advocacy. (Guest Editorial)
    Curr. Sci. 116, 345–346 (2019)
  5. Saberwal G
    Our educational system is unlikely to enable super-power status for India any time soon (Guest Editorial)
    Curr. Sci., 116, 509–510 (2019)
  6. Saberwal, G.
    Cuba: A different kind of role model for biotechnology
    Current Science 115, 1835–1836 (2018)
  7. Saberwal, G.
    Bio-business in brief: What ails clinical trials?
    Current Science 115, 1648–1652 (2018)
  8. Mukherjee, S. and Saberwal, G.
    Managing India’s AIDS crisis in the 2000s: Quantitative modeling had impact.
    Current Science 114, 2005–2006 (2018) (Guest Editorial)
  9. Saberwal, G.
    Regulatory harmonization: a view from India. (Guest Editorial)
    Current Science. 114, 423–424 (2018).
  10. VijayRaghavan, K. and Saberwal, G.
    Bio-business in brief: The case for ambitious action in the public sector
    Current Science 113, 1841–1845 (2017).
  11. Saberwal, G.
    Supporting start-ups (Guest Editorial)
    Current Science 113, 195–196 (2017).
  12. Venkatachalam, S. and Saberwal, G
    Bio-business in brief: A case for new drugs at generic prices from India
    Current Science, 102, 13751-1381 (2012)
  13. Saberwal, G
    Translating academic discoveries
    Current Science 103, 767-769 (2012)
  14. Saberwal, G
    Bio-business in brief: A bit about technology transfer
    Current Science, 99, 177-180 (2010)
  15. Saberwal, G
    Bio-business in brief: The debate over biosimilars
    Current Science, 98, 1575-1578 (2010)
  16. Saberwal, G
    Bio-business in brief: The paradox of being a drug company
    Current Science, 97, 623-625 (2009)
  17. Devaguptapu, S, Mehdiratta, R and Saberwal, G
    Bio-business in brief: The case of Cytokinetics Inc.
    Current Science, 94, 1576-1581 (2008)
  18. Mehdiratta, R,  Parida, D K and Saberwal, G
    Bio-business in brief: The challenges of clinical trials
    Current Science, 93, 1367-1375 (2007)
  19. Mehdiratta, R and Saberwal, G
    Bio-business in brief: Many a monoclonal.
    Current Science, 93, 789-796 (2007)
  20. Mehdiratta, R and Saberwal, G
    Bio-business in brief: The case of conotoxins.
    Current Science, 92, 39-45 (2007)

Perspectives And Other Articles

  1. Saberwal, G.
    Interview by BioStandups (August, 2017)
    (http://www.biostandups.com/face-of-the-month/#1505358038267-1cd8a74f-9174)
  2. Saberwal, G.
    On being a professional mutant.
    Nature Biotechnology, 32, 106-107 (2014)
  3. Saberwal, G
    Caring for a severely disabled person.
    Available here.
  4. Kapoor, M. and Saberwal, G
    The new crossroads
    Biotech News, 5, 143-145 (2010).
  5. Saberwal, G.
    Drug development in India: What does the future look like?
    Contemporary Perspectives: History and Sociology of South Asia, Ed. N Tyabji, 3, 293-309 (2009)
  6. Saberwal, G
    A long march
    Biotech News, IV, 68-69 & 75 (2009)Saberwal, G.  Biotechnology Incubation in India.
    In Business incubation: Initiatives in India Ed. R. K. Lagu, brought out by NSTEDB, DST (2004)

Address

Institute of Bioinformatics and Applied Biotechnology
Biotech Park, Electronic City Phase I,
Bengaluru 560100,
India

Phone

285 289 00/01/02, extension 120

Email

gayatri[@]ibab(.)ac{.}in