Recent stories from around campus
Protein domains are crucial for determining protein functionality, serving as structural and functional units essential for diverse biological processes. This study delves into the intricate world of the structures of these domains, focuses on the strength of interactions within two-domain proteins and compares strong (permanent) and weak (transient) interations. The results provide better understanding of multi-domain protein structure, function and folding principles
This study hi2ghlights curcumin’s role as an epigenetic modulator in ovarian cancers. Curcumin modulated distinct miRNA regulatory networks to induce cellular cytotoxicities in two different ovarian cancer cell lines (PA1 and A2780) underscoring its cell-type-specific mode of action.
This study tested the activity of an HSP90 inhibitor, SP11, against leukemic cells, mouse lymphoma allograft, and xenograft models.
This study uses a multi-omics approach to understand the global gene expression and metabolite changes induced by Disarib, a novel Bcl2-specific inhibitor in the Ehrlich adenocarcinoma (EAC) breast cancer mouse model and shows that Disarib reduces tumours by reducing oncometabolite and activating apoptosis and downregulating angiogenesis.
Transcriptome data of Moringa concanensis Nimmo (MC) and M. oleifera (MO) have been compared. They are well-known for their abundance of molecules with medicinal properties. In terms of molecular abundance of secondary metabolites, expression of enzymes in the biosynthesis pathway and in vitro glucosidase inhibitory activity, the leaves of MC score higher.
We report the genome assembly of IndCh (Chennai, India) strain of An. stephensi, which is found to be homozygous for the standard form of the 2Rb chromosome configuration (2R+b/2R+b), allowing us to extract segregating SNP signatures and the identification of candidate genes responsible for the expansion range of this important malaria vector in India.
Curcumin is well known for its anticancer properties. Its cytotoxic activity has been documented in several cancer cell lines, including breast cancer. With the help of integrative analysis we have shown regulation of biomarker miRNAs and mRNAs pairs mediated by Curcumin.
This study provides a comprehensive transcriptional analysis of the Myxococcus xanthus developmental cycle while comparing it with the vegetative biofilms grown in rich and poor nutrients. It portrays several differentially expressed genes involved in key central metabolic pathways suggesting their role in regulating myxobacterial development.
This study analyzes the median ‘strain collection to genome submission time lag’ per country for 1.7 million SARS-CoV-2 strains. It recommends an effective SARS-CoV-2 genomic surveillance system focusing on increasing the sequencing potential and rapid genome submission to open access platforms like GISAID.
Progressive atrophic rhinitis in domestic pigs is caused by Pasteurella multocida strains containing toxA, which encodes a heat-labile toxin. Here, by comparative analyses of the genomes of many strains, it has been shown that toxA is sparsely distributed in P. multocida. Also, toxA is usually associated with a prophage, and some strains contain an orthologous prophage but not toxA.
The Methicillin-Resistant Staphylococcus aureus (MRSA) strain LVP-7 was isolated in India a few years ago. Here, we present its draft genome and identify key features that could explain its virulence properties. We are currently improving genome assembly using long-read sequencing and analyzing the transcriptome of this MRSA strain
Profilin regulates intracellular transport in Leishmania.
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