As part of our studies of drug discovery against SARS-CoV-2, we carried out in silico studies using 637 phytochemicals from spices and condiments used in the Indian Diet, against the viral helicase and one of human immune regularoty proteins.

Progressive atrophic rhinitis in domestic pigs is caused by Pasteurella multocida strains containing toxA, which encodes a heat-labile toxin. Here, by comparative analyses of the genomes of many strains, it has been shown that toxA is sparsely distributed in P. multocida. Also, toxA is usually associated with a prophage, and some strains contain an orthologous prophage but not toxA.

It is essential to register each clinical trial, providing complete and accurate data, in a timely fashion. We have quantified the widely divergent quality of 18 major public clinical trial registries, and have defined features of an interim ideal one.

The Methicillin-Resistant Staphylococcus aureus (MRSA) strain LVP-7 was isolated in India a few years ago. Here, we present its draft genome and identify key features that could explain its virulence properties. We are currently improving genome assembly using long-read sequencing and analyzing the transcriptome of this MRSA strain

Glutathione peroxidase 3 in various cancers, and its use as a prognostic biomarker and a potential target for clinical intervention.

The bovine (and ovine) opportunistic pathogen Histophilus somni contains luxS and forms a biofilm.
luxS mutant compared to that in the wild-type, whether the bacteria were grown planktonically or in a biofilm.

Transcriptomic meta-analysis of expression pattern among smoking lung cancer patients identified 9 gender-biased genes, consistent across at least 4 studies.

The use of protein–protein interaction networks to unravel the mechanism of action of Curcuma longa L bioactives.

A chromosome-level genome assembly of the first malaria vector from India reveals genes within an inversion locus linked to insecticide resistance.

Active at nanomolar concentrations, ST09 can potentially be developed as a novel antitumor drug candidate for highly metastatic and aggressive breast cancer.

A novel moving-window based approach using RNA-Seq data was developed to detect context-dependent expression of small RNAs in M. tuberculosis.

10s or 100s of regulatory trials that have run in India appear not to have been registered with Clinical Trials Registry-India (CTRI), as required by the law.

Whole-genome and pan-genome analysis of 167 SARS-CoV-2, 312 SARS-CoV, and 5 Pangolin CoV isolates to understand the diversity and evolution of Coronaviruses

Systematic, multi-omic data analysis in M. smegmatis highlighted significant expression and translation signals in the pseudogene regions, calling for the re-annotation of bacterial pseudogenes.

Profilin regulates intracellular transport in Leishmania.

Myosin 21, a novel form of myosin with two UBA-like domains in its tail region, regulates flagellum assembly, intracellular vesicle transport and cell motility in Leishmania promastigotes.

By comparing the crt loci, the carotenogenesis pathway, and the possible origins of two strains of Sphingomonas echinoides, have been proposed.

Arbitrary selection of bioinformatic resources hurts science. Our results help objective choice of ‘protein-protein interaction’ databases/tools.

Combined genomic and functional network analyses were performed to predict biofilm and quorum-sensing associated proteins in M. tuberculosis.

Green synthesis of silver nanoparticles (ST06-AgNPs) using curcumin derivative (ST06) on EAC tumor bearing mice models

Various deficiencies in the data of interventional drug trials registered with Clinical Trials Registry – India were identified.

Phylogenetic analysis using 16S rDNA and deduced proteome sequences facilitated the identification of several novel species of the genus Chryseobacterium.

Superposition of crystal structures of the arsenic responsive regulatory protein – ArsR, in complex with trivalent arsenic ion, from a couple of microbial species.

Effects of rheumatoid arthritis associated transcriptional changes on osteoclast differentiation network in the synovium

A novel molecular mechanism for a long non-coding RNA PCAT92 implicated in prostate cancer