Dr. Rajalakshmi Srinivasan
Research Focus Keywords:
Microbial Genomics, Amino acid signalling, Transcriptional Regulation, Genomics of aging, Mitochondrial biogenesis and ribosomal biogenesis
Dr. Rajalakshmi Srinivasan, graduated with a master degree in biotechnology from SASTRA University,Tanjavur. As a DST-INSPIRE Fellow, she joined Dr. Aswin Seshasayee’s group at National Centre for Biological Sciences for her Ph.D. She completed her Ph.D in bacterial genomics and received her degree from Manipal University. Later, she moved to the Institute for Stem Cell Science and Regenerative Medicine for her post-doctoral research with Dr. Sunil Laxman, where she studied the coupling between metabolism, transcription and translation in yeast. She identified a function of a conserved transcription factor in coupling metabolic outputs with the transcriptional and translational outputs. She has received several fellowships from various leading agencies, DST-INSPIRE Faculty Fellowship, M. K. Bhan Young Researcher Fellowship, SERB-National postdoctoral fellowship, DBT-RA, to name a few. She joined IBAB in October 2021 as DST-INSPIRE Faculty Fellow. Here, her lab aims to understand the impact of transcriptional response induced by amino acid signaling on cellular aging using budding yeast as a model system.
- Postdoc: Institute for Stem Cell Science and Regenerative Medicine, India (2017-2021)
- Ph.D: National Centre for Biological Sciences, India (2011-17)
- M.Sc (Biotech): School of Chemical and Biotechnology, SASTRA University, Tanjavur, India (2008-10)
- B.Sc. (Biotech): Sri Paramakalyani College, Manonmaniam Sundaranar University, Tamil Nadu (2005-08)
One of our research focuses is to understand amino acid dependent gene regulatory mechanisms on several hallmark processes of aging. While amino acid restriction or the excessive supply has been shown to affect aging, several pathways underlying this regulation is not known. Using budding yeast as a model system and by employing a wide range of approaches such as genomics, molecular, microscopic and system level approaches, her group will explore following research areas.
1. Elucidating the regulatory mechanisms behind amino acid dependent regulation of ribosomal biogenesis and mitochondrial biogenesis.
2. Role of amino acid dependent transcriptional regulation on the cellular and organismal lifespan.
In addition to this, her group will also work on uncovering the evolutionary importance of transcription factors binding on the specific macrodomains of the chromosome and its role in deciding septum formation site during bacterial cell division.
Applicants with fellowships from any national agencies will be considered for a JRF position. Interested candidate please send your CV and a one page write up on your scientific goal to email@example.com
List of Publications
- Z. Rashida, R. Srinivasan, M. Cyanam, S. Laxman., Kog1/Raptor mediates metabolic rewiring during nutrient limitation by controlling SNF1/AMPK activity. Science Advances 2021. DOI: 10.1126/sciadv.abe5544
- Srinivasan R, Walvekar AS, Rashida Z, Seshasayee A, Laxman S. Genome-scale reconstruction of Gcn4/ATF4 networks driving a growth program. PLOS Genet. 2020. doi:10.1371/journal.pgen.1009252
- Walvekar AS, Kadamur G, Sreedharan S, Gupta R, Srinivasan R, Laxman S. Methylated PP2A stabilizes Gcn4 to enable a methionine-induced anabolic program. J Biol Chem. 2020. doi:10.1074/jbc.ra120.014248
- Walvekar AS, Srinivasan R, Gupta R, Laxman S. Methionine coordinates a hierarchically organized anabolic program enabling proliferation. Mol Biol Cell. 2018. doi:10.1091/mbc.e18-08-0515
- Srinivasan R, Scolari VF, Lagomarsino MC, Seshasayee ASN. The genome-scale interplay amongst xenogene silencing, stress response and chromosome architecture in Escherichia coli. Nucleic Acids Res. 2015. doi:10.1093/nar/gku1229
- Srinivasan R, Chandraprakash D, Krishnamurthi R, Singh P, Scolari VF, Krishna S, et al. Genomic analysis reveals epistatic silencing of ‘expensive’ genes in Escherichia coli K-12. Mol Biosyst. 2013;9: 2021–33. doi:10.1039/c3mb70035f
- Prabhakara S, Khedkar S, Shambat SM, Srinivasan R, Basu A, Norrby-Teglund A, et al. Genome Sequencing Unveils a Novel Sea Enterotoxin-Carrying PVL Phage in Staphylococcus aureus ST772 from India. PLoS One. 2013. doi:10.1371/journal.pone.0060013
Awards and Fellowships
|DBT- M.K Bhan Young|
|Department of Biotechnology (DBT)||2021-24|
Registration Fee Waiver
|EMBL Corporate Partnership Programme||2021|
|EMBO travel award||EMBO conferences||2020|
|DST||SERB-National Post-Doctoral Fellowship||2017-19|
|NCBS||Bridging Post-Doctoral Fellow||2016-17|
(declined to take up DST-SERB fellowship)
|DST ||INSPIRE Fellowship||2011-16|
|DST ||CTEP -Travel grant||2013|
|NCBS||Best poster award- (International travel grant)||2013|
|Indian Academy of Sciences ||Summer Research Fellowship||2010|
|Indian Academy of Sciences||Summer Research Fellowship||2008|
|SASTRA University||University Gold medallist||2010|
Presentations (Posters* and Talks**)
2021: Chromatin and epigenetics -2021- EMBL Conference, Virtual*
2020: International Conference on Autophagy and Lysosomes , IISc , Bangalore
2018: Aspects of Gene and Cellular Regulation , Institute of Mathematical Sciences, Chennai**
2017: Young Scientist Research Symposium, The Wellcome Trust/DBT India Alliance, IIT, Madras*
2013: Quantitative methods in Gene Regulation II, Institute of Physics, Cambridge, UK**
2013: Bacterial Gene Expression I, National Centre for Biological Sciences, Bangalore*
|Name: Sampreeth Gowda|
Background: MSc Biochemistry
Designation: Project Assistant
I completed my MSc in Biochemistry from Padmashree Institute of Management and Sciences, Bengaluru in 2018. I have worked as Scientific analyst in Molecular connections Pvt. Ltd. in 2019. I have also worked as Project Associate in COVID facility at inStem-NCBS. I joined the lab in March 2022 as a Project Assistant and my research interest lies in studying amino acid dependent regulation of mitochondrial DNA maintenance and its role in aging.
|Name: Soujanya Nagendra|
Background: Int. MSc. Biological Science
Designation: Project Assistant
I have completed my Integrated BSc-MSc from the Department of Life Science, Bangalore University in 2021. I joined IBAB as a Project Assistant in April, 2022 and my research work focuses on understanding the role of amino acid dependent transcriptional regulation on the chronological lifespan of yeast.
|Name: Jeevitha P|
Background: (Int. MSc.) Biological Science
I am currently in my last semester as a master student in Integrated BSc-MSc Biological Science from the Department of Life Science, Bangalore University. I joined the lab in June, 2022 and my research work focuses on understanding the role of amino acids on vacuolar morphology and biogenesis in yeast.
|Name: Anjitha S|
I am currently in my last semester as a master student in MSc Biotechnology from the St. Berchmans College, Mahatma Gandhi University. I joined the lab in April, 2022 and my research work focuses on understanding the expression of ribosomal protein gene regulators in response to amino acid signals.
Ms. Ankana Banerjee, Project Intern, Msc10, IBAB , currently in Strands Lifesciences
Ms. Anshika Saxena, Intern M.Tech, Biotechnology , BITS-Pilani-Hyderabad Campus, currently in Biocon
Ms. Namia Ahmad, Intern, M.Sc-Biotechnology, St. Joseph’s college, Bangalore